Are FMRI Data Analysis Methods Reliable?

There’s been a lot of discussion on social media of a recent paper in PNAS by Anders Eklund, Tom Nichols, and Hans Knutsson.
Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates
Even Science magazine felt they needed to address it. What is this fuss all about?

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What are Computational and Systems Neuroscience?

One of the fundamental questions motivating neuroscientists is to understand the relationship between brain activity and lived experience: how the different parts of the brain work together to produce the key ingredients for behavior: memory, feeling, thinking and imagination. These motivating issues have been pretty much inaccessible for most of the history of neuroscience, because we could not observe very much of the brain in action in enough detail to identify individual circuits or on the time scale on which they work. That is starting to change.

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